Abstract: OBJECTIVE To review the advance in the research of the 2019 Novel Coronavirus(SARS-CoV-2), with a view to providing reference for research related to outbreak prevention and control. METHODS On the basis of the latest domestic and foreign articles, the progress of genomics research of SARS-CoV-2 were summed up. RESULTS & CONCLUSION Evolutionary analysis based on genomic sequences suggested that the virus may evolve adaptively during the process of human-to-human transmission and infection, which may affect the effectiveness of current detection and diagnosis. It is suggested that the whole genome-based evolutionary analysis of large-scale virus isolates and wild animals carrying virus strains should be carried, and the adaptive evolution mechanisms of virus variation should be monitored and analyzed, which can provide research basis for epidemic prevention and control.