Abstract: OBJECTIVE To analyze the efficacy of simvastatin combined with Shengmai powder and Xuefu Zhuyu decoction in the treatment of coronary heart disease(CHD). METHODS One hundred and eight patients with CHD of qi-yin deficiency and blood stasis syndrome who were admitted to Qianxi Traditional Chinese Medicine Hospital from February 2017 to February 2018 were selected and divided into two groups by random number table method. The control group(54 cases) was treated with simvastatin, and the observation group(54 cases) was treated with Shengmai powder and Xuefu Zhuyu decoction on the basis of the control group. The curative effect of the two groups and the changes of relevant indexes before and after treatment were analyzed. RESULTS The total effective rate of cardiac function improvement in the observation group was 90.73%, which was significantly higher than 75.93% in the control group(P<0.05). The therapeutic effect of traditional Chinese medicine syndrome in the observation group was 92.58%, which was higher than 77.78% in the control group(P<0.05). Before the treatment, the levels of cardiac function, cardiac ultrasound parameters, blood lipids, inflammatory factors and hemorheology indexes in the two groups were not statistically significant. After treatment, the observation group of echocardiographic parameters of left ventricular end-diastolic diameter(LVEDD), blood lipid levels of total cholesterol(TC), three acyl glycerin(TG), low density lipoprotein cholesterol(LDL-C), the hs-CRP, IL-6 and TNF-α and hemorheology index levels significantly lower than the control group(P<0.05), left ventricular ejection fraction(LVEF), E/A, left ventricular short axis shortening rate(△FS) and high density lipoprotein cholesterol(HDL-C) level was significantly higher than that of control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups, and there was no significant change in aspartate aminotransferase, alanine aminotransferase and creatine kinase levels before and after treatment. CONCLUSION Simvastatin combined with Shengmai powder and Xuefu Zhuyu decoction can significantly improve the cardiac function of CHD patients, reduce TC, TG, LDL-C, hemorheology and inflammatory factors, and increase the level of HDL-C.