Abstract: OBJECTIVE To investigate the pharmaceutical care of patients with advanced Parkinson's disease with complicated motor complications. METHODS By participating in the treatment of a Parkinson's disease patient with complicated motor complications, analyzed and summarized the pharmaceutical services on the patient. RESULTS Clinical pharmacist provided rational suggestions on the drug selections, and conducted the evaluation and treatment of adverse drug reactions with professional knowledges. Finally, the improvement was seen in this patient. CONCLUSION Clinical pharmacist can provide pharmaceutical service on patients with Parkinson's disease, which will improved the safety of patients.