Abstract: OBJECTIVE To investigate the mechanism of constituents migrating to blood of Jinqi Jiangtang tablet in treating diabetes mellitus based on network pharmacology. METHODS Searched literature to obtain constituents migrating to blood of Jinqi Jiangtang tablet, screened targets corresponding to the constituents migrating to blood in TCMSP and Swiss Target Prediction databases, and found the targets of diabetes from GeneCards database, anti-diabetic targets of constituents migrating to blood were obained by their intersection. The results were imported into Cytoscape software to construct a network of constituents migrating to blood anti-diabetic targets. Used STRING platform to construct a PPI network, imported the network to Cytoscape software to calculate topological parameters, and picked out key targets; the gene ontology(GO) function enrichment analysis was performed by "ClueGO" plug-in; the DAVID database was used for KEGG pathway enrichment analysis. RESULTS Sixteen constituents migrating to blood of Jinqi Jiangtang tablet acted on 123 diabetic targets. Twenty two key targets included inflammatory factors:IL1β, IL6, IL8, TNF, and PTGS2; redox reaction enzymes:CAT, SOD1, MAOB; cardiovascular targets point:TBXA2R, VEGFA, NOS3; cell cycle and apoptosis proteins:CDK2, MAPT, CASP3, et al. They involved in 14 major biological processes such as regulation of acute inflammatory response, negative regulation of extrinsic apoptotic signaling pathway, regulation of monooxygenase activity, and hydrogen peroxide biosynthetic processe, and regulated multiple signaling pathways such as insulin resistance, type I diabetes mellitus, TNF signaling pathway, NF-κB signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway. CONCLUSION Jinqi Jiangtang tablet mainly has pharmacological effects such as anti-inflammatory, anti-oxidation, regulation of apoptosis and glucose metabolism, alleviates islet β-cell damage, reduces insulin resistance, finally produces anti-diabetic effect.