Abstract: OBJECTIVE To explore the role of clinical pharmacists in nutrition support treatment by optimizing intervention and providing pharmaceutical care for the nutritional supportive program for a very low birth weight infant with necrotizing enterocolitis(NEC). METHODS The initial parenteral nutrition support program for the very low birth weight infant was optimized, and the nutritional support program was timely adjusted when the infant was complicated with NEC and hypertriglyceridemia associated with parenteral nutrition. RESULTS It was safe to give amino acids in 24 h after birth. When the infant was diagnosed with NEC, she or he should be fasted and supported with parenteral nutrition totally instead. When symptom of high triglycerides developed, the amount of fat emulsion should be reduced. CONCLUSION The formulation and adjustment of infant's nutritional support program shall be individualized to achieve a more satisfactory therapeutic effect.