Abstract: OBJECTIVE To investigate the questions of pregnant askers in the pharmacist outpatient with risk assessment and communication of drugs in pregnancy, pharmacists understood the basics of pregnancy medication, and screened out typical cases, then explored the influencing factors and principles of drug safety during pregnancy. It provided reference for safe drug use in women during pregnancy. METHODS Communicated with 3 405 questioners directly in this counseling outpatient during September 2012-August 2017, and then consulted, communicated, educated and recorded. RESULTS The consultants with female were 90.84%; with male were 9.16%. The chief problem was drug-used in pregnancy, 59.15% counselors were took drugs before the diagnosis of pregnancy; 37.53% counselors were used drugs during pregnancy; 3.32% ones asked questions other than medicines. To select the typical and special records with medicaitons in gestation, the clinic pharmacists focused on assessing the teratogenic risk of drugs on fetus. These cases involved progesterone, estrogens, hypoglycemic agents, antibiotics, psychotropic substances, anticoagulants, and stimulants used by both parents. CONCLUSION It is targeted that the pharmacists carried out this individualized pharmacy services for gravidas in outpatient. It not only gets more knowledge for pregnant women, but also enhances their attitudes of medications, even improves the professional knowledge of clinical pharmacists.