Abstract:
OBJECTIVE To explore the characteristics of Chinese herbal compound in the treatment of transient cerebral ischemia(TIA).
METHODS With CNKI, Wanfang date, VIP database as a sources, the subject of "transient cerebral ischemia+clinical" and the full text of "traditional Chinese medicine(TCM)" were used for advanced retrieval, and the periodical literatures related to the treatment of TIA with TCM from 1977 to 2019 were screened and classified, and the related TCM compound or Chinese medicine preparation were screened out, and the medicine taste was entered into the Excel table database, and the data were analyzed by SPSS Statistics 23.0 and SPSS Modeler 14.1 statistical software.
RESULTS Among the 67 prescriptions included, 125 kinds of TCM were involved in total, and 19 kinds of TCM were used with frequency ≥ 10. Chuanxiong(38 times, 56.72%), salvia miltiorrhiza(33 times, 49.25%), angelica(26 times, 38.81%), safflower(25 times, 37.31%), astragalus membranaceus(25 times, 37.31%) and gastrodia elata(25 times, 37.31%) were the most common. According to the statistics of TCM with medication frequency ≥ 2, in the treatment of TIA, TCM for activating blood and removing blood stasis(174 times, 28.90%), tonifying deficiency(135 times, 22.43%), and soothing liver and wind polyps(74 times, 12.29%) were mostly used. The main drugs were "warm(200 times, 33.50%), flat(157 times, 26.30%)", and "gump(303 times, 32.41%), bitter(278 times, 29.73%)". There were many TCM in the middle liver meridian(426 times, 29.20%). A total of 20 TCM combinations with high support were obtained by association rule analysis, and 6 common factors and 6 cluster combinations were obtained by factor analysis and system clustering analysis.
CONCLUSION The data analysis results shows that in the clinical treatment of TIA, drugs for activating blood circulation and removing blood stasis, tonifying deficiency, liver polyps and heat-clearing drugs are mainly used as auxiliary drugs, and TCM with mild property, sweet taste and liver meridian are mainly selected. The compatible use of TCM such as chuanxiong, angelica, salvia miltiorrhiza, safflower and astragalus are mainly considered.