Abstract: 2019 novel coronavirus(2019-nCov, nCov) infections appeared in Wuhan in December 2019, and widespread in China. Currently, there is no specific antiviral drugs for nCov infections. Based on studies of other similar viruses, lopinavir/litonavir, interferon-α, ribavirin, abidol, darunavic/cobicistat and radesivir were used to fight pneumonia caused by nCov infection. The first affiliated hospital, college of medicine, zhejiang university is the designated hospital for the diagnosis and treatment of nCov infection. Based on this, it is recommend that the optional antiviral drugs for children, pregnant women, elderly patients, patients with mechanical ventilation, liver and kidney dysfunction, patients receving extracorporeal membrane oxygenation or renal replacement therapy with nCov infections, aiming at providing more effective and safe antiviral treatment for patients.