Abstract: OBJECTIVE To improve the focus of physicians on bulla epidermal necrotic drug rash and improve the clinical thinking of clinical pharmacists. METHODS Consultation of bulla epidermal necrotic drug rash was made by pharmacists. The clinical thinking of pharmacists was summarized. RESULTS Clinical pharmacists were helpful in determining the suspected drug and adjustment of drug therapy. Consultation was helpful in improving the recognition of clinical pharmacists. CONCLUSION It is significance for clinical pharmacists to actively participate in clinical treatment programs and pay attention to adverse drug reactions to improve the treatment effect and reduce the occurrence of drug-induced diseases.