Abstract: OBJECTIVE To explore the effects of nifedipine combined with enoxaparin sodium on blood pressure, coagulation function and serum D-dimer in patients with severe preeclampsia. METHODS The 203 pregnant women with severe preeclampsia who were delivered by cesarean section were selected from June 2015 to October 2017. According to the random comparison table, they were divided into control group (101 cases) and observation group (102 cases). The control group was treated with nifedipine, while the observation group was treated with nifedipine combined with enoxaparin sodium. The changes of blood pressure, coagulation function and serum D-dimer were compared between the two groups, and the adverse pregnancy outcome were analyzed. RESULTS The total effective rate of observation group was 95.10%, significantly higher than that of control group(87.13%), with statistical difference(P<0.05). After treatment, FIB, D-dimer, PAI-1, HB, PLT decreased significantly in the observation group, while PT, APTT, t-PA increased significantly, and the level of each index was better than that in the control group(P<0.05). After treatment, the systolic and diastolic blood pressures of the two groups were significantly decreased, and the blood pressure level of the observation group was significantly lower than that of the control group (P<0.05). After treatment, the serum vWF and PAPP-A levels in both groups were significantly decreased, and the levels in the observation group were significantly lower than those in the control group(P<0.05). The mean gestational time and fetal weight in the observation group were significantly better than those in the control group, and the 24-hour proteinuria level in the observation group was significantly lower than that in the control group. The main adverse pregnancy outcomes were fetal distress, premature delivery, postpartum hemorrhage, neonatal asphyxia. The incidence of adverse pregnancy in the observation group (9.80%) was significantly lower than that in the control group (18.81%), with statistical difference(P<0.05). CONCLUSION Nifedipine combined with enoxaparin sodium is effective in the treatment of severe preeclampsia. It can effectively reduce postoperative blood pressure, improve coagulation function, regulate serum D-dimer level after operation, thereby reducing the incidence of adverse pregnancy outcome.