Abstract: OBJECTIVE To improve the operational efficiency of drug clinical trial institution, eliminate the drawbacks of traditional operational procedures, and explore new management models. METHODS Based on the existing HIS/LIS foundation, taking into account the cost and function, the multi-disciplinary department jointly designed and implemented medical ordering and settlement information system, and gradually revised the function after trial operation. RESULTS The on-line of the system not only enabled institution to fully support outpatients or hospitalized patients to participate in clinical trials with medical insurance or self-paid cards, but also saves a lot of manpower and material resources in various aspects such as trial fund reimbursement. Data traceability was also strengthened. CONCLUSION Informatization is the trend of the development of drug clinical trial institutions. The successful development and operation of this system provides a reference example for other drug clinical trial institutions to solve such problems.