Abstract: OBJECTIVE To analyze and research the volatile chemical components in the edible drug Cicutae Fructus. METHODS GC-MS combined with chemometric technology were used for qualitative analysis of the volatile oil from Cicutae Fructus. The automatic mass spectral deconvolution and identification system(AMDIS) was used to resolve overlapping peaks in chromatograms; meanwhile,the temperature-programmed retention index for assistant identification was employed; finally the pure components were qualitatively analyzed by mass spectrum library. RESULTS Thirty-one compounds of the whole extracts of Cicutae Fructus were identified, which were mainly alkenes, aldehyde and alcohols. The highest level compound was γ-terpinene(66.29%). CONCLUSION The method can be more really and comprehensively reflect the essential oil components in Cicutae Fructus. The study will provide foundation for a further development and quality control of Cicutae Fructus.