Abstract: OBJECTIVE To optimize the processing technology for prepared Anemcme raddeana Regel(A.R). METHODS The single factor experiment was used to optimize the dilution ratio of rice wine. Based on the contents of raddeanin A, response surface methodology(RSM) was used to optimize the rice wine dosage, moistened time, stir-fried temperature and stir-fried time in the processing technology for prepared A.R. RESULTS The optimal processing technology for prepared A.R was mixed with 32.79% rice wine, moistened for 61.59 min, and stir-fried for 43.85 min at 81.55℃. CONCLUSION The processing technology for prepared A.R optimized by RSM can be used to optimize the process parameters, promote the stability and repeatability of the processing technology, which can significantly control the inner quality of prepared A.R. to ensure effectiveness in clinical application.