Abstract: OBJECTIVE To study the general regularity and risk factors of adverse drug reactions to skin necrosis induced by terlipressin, to provide reference for the rational use of drug in clinical. METHODS Reported one case of skin necrosis caused by terlipressin, searched related literature and statistical analysis. RESULTS The skin necrosis caused by terlipressin was mainly in males(76.67%) and over 50 years old(73.33%), the time of high incidence of adverse reactions was 5 d before medication(83.33%), mainly in trunk and limbs. Low blood volume, obesity, alcoholic liver cirrhosis, combined use of vasoactive drugs may high risk factors of skin ischemia caused by terlipressin. CONCLUSION The clinical use of terlipressin should pay attention to the adverse reactions caused by necrosis of the skin, and pay close attention to the application process, early detection and early treatment.