Abstract: OBJECTIVE To establish and compare the UPLC fingerprint of Chuanxiong Rhizoma, broken wall piece, standard decoction and formula granules, analyze its similarity and conduct cluster analysis (CA) and principal component analysis (PCA) for different forms of Chuanxiong Rhizoma, so as to provide quality control basis for different forms of Chuanxiong Rhizoma. METHODS The separation was carried out on a Waters ACQUITY UPLC BEH C₁₈(2.1 mm×100 mm, 1.7 μm) with the mixture of acetonitrile and 0.1% phosphoric acid as the mobile phase in a gradient elution model at a flow rate of 0.3 mL·min^-1, the detection wavelength was 276 nm, the column temperature was 35℃, and the sample volume was 2 μL. Twelve batches of Chuanxiong Rhizoma medicinal materials and the standard decoction, 7 batches of broken wall piece, and 6 manufacturers of Chuanxiong Rhizoma formula particles were detected. All of samples were analyzed using the evaluation system of Traditional Chinese Medicine Chromatographic Fingerprint Similarity(2012 Version) and using SPSS 22.0 statistical software for chemical pattern recognition analysis. RESULTS The similarity of different forms of Chuanxiong Rhizoma was >0.9, and the similarity of different forms of Chuanxiong Rhizoma was 0.534, 0.449, 0.979 and 0.968, respectively. Cluster analysis and principal component analysis revealed the similarities and differences between the different forms of Chuanxiong Rhizoma. CONCLUSION Based on the fingerprint data, combining the CA and PCA, it can be seen that the quality of different forms of Chuanxiong Rhizoma is stable. In addition, the similarity between broken wall piece and the medicinal materials is higher, and the similarity between standard decoction and formula granules is higher.