Abstract: OBJECTIVE To systematically analyze the efficacy and safety of compound glycyrrhizin combined with narrow bound ultra violet B light(NB-UVB) in the treatment of psoriasis. METHODS Full-text databases of Chinese periodicals, Cochrane Library, Wanfang Digital Periodicals and Medline were searched by computer. All randomized controlled trials(oral antihistamines or/and glucocorticoids) of the clinical efficacy of single routine therapy and compound glycyrrhizin tablets combined with NB-UVB in the treatment of psoriasis were collected. The literature was screened, quality evaluated, and publication biased, and the efficacy and safety of compound glycyrrhizin in the treatment of psoriasis were analyzed. RESULTS Eleven articles were finally grouped. The literature included 552 patients in the control group and 584 patients in the experimental group. Eleven studies reported the results of clinical comparison of compound glycyrrhizin tablets in the treatment of psoriasis. The total effective rate(marked efficiency+cure rate+improvement rate) was used as a meta-analysis index. The homogeneity of 11 studies was tested and found to be homogeneous among 11 studies(P=0.60, I²=0%). Therefore, meta-analysis of 11 sets of data was performed using a fixed-effect model. The meta-analysis results showed that the combined OR value was 0.23(95%CI:0.17-0.31), and the significance test statistic Z=9.57(P<0.05). Nine studies reported adverse reactions during the experimental process, and homogeneity analysis showed that there was homogeneity between them(P=0.63, I²=0%). Meta analysis used fixed-effect models for analysis. The OR value of the experimental combination was 2.70(95%CI:1.45-5.02), and the significance test Z=3.14(P<0.05). CONCLUSION Compound glycyrrhizin combined with NB-UVB treatment of psoriasis has obvious effect, but there will be a certain degree of adverse reactions.