Abstract: OBJECTIVE To evaluate the application of non-steroidal anti-inflammatory drugs(NSAID) in a Grade III B hospital in postoperative analgesia and analyze its rationality. METHODS Using the electronic case and other HIS system and rational drug use software, 3 905 inpatients who received NSAIDs after operation from January to December 2018 were selected for retrospective evaluation. RESULTS A total of 3 905 patients were treated with NSAIDs after operation, including 1 406 cases of unreasonable cases and 27 cases of adverse reactions, which were mainly in the departments of hand and foot surgery, orthopedics and urology. The main manifestations of irrational use of drugs were inappropriate dosage and Drug delivery mode (1 375 cases, 35.21%), combined use (179 cases, 4.58%) and improper drug selection (48 cases, 1.23%), overprescriptive medication (8 cases, 0.20%). The use of NSAIDs was unreasonable after surgery in this hospital, 85.28% of the unreasonable cases were selected for intravenous drip in the mode of administration. CONCLUSION Clinicians should strictly follow the drug instructions, in addition, hospitals should timely transmit rational drug use information to clinicians, carry out rational drug use education, control the usage of non-steroidal anti-inflammatory injection by means of information technology, etc. Various measures should be taken to ensure the safe use of drugs and to promote the rapid recovery of postoperative patients.