Abstract: OBJECTIVE Process optimization of extraction, concentration, drying, and granulation of Fructus Corni formula granules. METHODS The extraction process of Fructus Corni was optimized by orthogonal design, and the processes of concentration, drying and granulation were optimized by a single-factor experiment method. RESULTS The optimized extraction process parameters were as follows:water of 8.0 mL·g^-1, soaking for 30 min, extract twice, and 30 min of extraction time. Spray drying was recommended with inlet air temperature of 180℃, outlet air temperature of 85℃, and concentrate density of 1.03 g·mL^-1. Dry granulation was favored with roller speed of 10.0 r·min^-1 and roller pressure of 9.2 MPa. CONCLUSION The optimization results of extraction, concentration, drying, and granulation processes can help to implement the industrial production of Fructus Corni formula granules.