Abstract: OBJECTIVE To establish a module of omeprazole for evaluating the prescriptions of essential medicines so as to promote the rational use of essential drugs, reduce drug expenses and save medical costs. METHODS To collect essential drug use data with the help of hospital information system, central prescription examination system and clinical rational drug use software of the First Affiliated Hospital of Soochow University, developed a module for evaluating the prescriptions of essential medicines, then evaluated the "availability" and "rationality" of essential drug use. Evaluate problems in the use of essential drugs in a timely and accurate manner and made intervention and improvement. RESULTS According to the requirements of basic drug prescription review, an information platform of basic drug prescription review system was developed based on omeprazole model. CONCLUSION Based on omeprazole model, the basic drug prescription review module program has established an information-based, modular and standardized prescription review system, which can be used for reference and promotion of other drug prescription information review.