Abstract: OBJECTIVE Based on network pharmacology, the material basis and molecular mechanism of divaricate saposhnikovia rootsmoked plum for the treatment of urticaria were analyzed. METHODS According to literature reports, the active ingredients and targets of divaricate saposhnikovia rootsmoked plum were screened in TCMSP database and BATMAN-TCM database in combination with oral bioavailability (≥ 30%) analysis and resistance (≥ 0.18). Urticaria targets were screened in the GeneCards database, and urticaria target with active ingredients were determined by target mapping. Cytoscape 3.5.1 software was used to construct the active component-target network, and the STRING platform was used to construct the target protein interaction network. Biological information annotation database (DAVID) was used to analyze KEGG signaling pathways of the target. The BiNGO and MCODE plug-ins in Cytoscape software were used to enrich and cluster the target genes in the GO biological process. RESULTS Sixteen active ingredients, such as quercetin, kaempferol, wogonin, imperatorin and cimifugin, were screened from the divaricate saposhnikovia rootsmoked plum, acting on 62 urtical-related targets such as Interleukin-6(IL-6), Tumor necrosis factor(TNF), Proto-oncogene tyrosine-protein kinase Src(SRC), Epidermal growth factor receptor(EGFR), Interleukin-8(IL-8), and Prostaglandin G/H synthase 2(PTGS2), regulating eight signaling pathway such as the tumor necrosis factor(TNF) signal channel, phosphoinositide 3 kinase/serine/threonine protein kinase signaling pathway (PI3K/Akt), nuclear transcription factors-κB signaling pathways (NF-kappa B), HIF-1 signaling pathways (HIF-1), NOD like receptor signaling pathways(NOD), participating in the regulation of inflammatory reactions, peptide-tyrosine phosphorylation, protein catabolism and other major biological processes. CONCLUSION It fully reveals the scientific connotation of divaricate saposhnikovia rootsmoked plum medicine in treating urticaria with multiple components, multiple targets and multiple pathways.