Abstract: It has unique advantages to use metabolomics in analyzing asthma, which is a complex disease. In order to improve the understanding of the pathophysiology of asthma and clinical diagnosis, therefore, this paper refer to nearly five years of metabonomics literature associated with asthma. Based on the literatures, this paper summarizes three major substances metabolism and metabolite about asthma, in order to provide a reference for the metabolomics research and clinical diagnosis, therapy of asthma.