Abstract: OBJECTIVE To explore the supply mode of special pharmacy to improve the accessibility of medicare negotiate drugs. METHODS Through the analysis of the supervision and supply mode of professional pharmacy in the United States, the paper summarized the advanced experience of the United States and the current status of the existing "special drug pharmacies" in China. RESULTS & CONCLUSION To promote the development of special pharmacy in China, it is necessary for medical insurance, hospitals, pharmaceutical companies, and pharmacies to form a joint effort to jointly improve the accessibility and affordability of "special drugs".