Abstract: OBJECTIVE To provide reference for physicians to establish individualized treatment of vancomycin. METHODS Clinical pharmacists applied the the population pharmacokinetic(PPK) model to adjust the dosage of vancomycin and to provide pharmaceutical care for a neonate with septicemia complicated with meningitis. RESULTS The infection in this neonate was effectively controlled following intravenous combined with intraventricular injection of vancomycin based on therapeutic drug monitoring and PPK model, and there were no vancomycin-caused adverse reactions. CONCLUSION Pharmacist can optimize the antiinfective treatment of vancomycin and help physicians to eatabilish the individualized treatment with PPK model.