Abstract: OBJECTIVE To explore the therapeutic effect of Junzi Xiaopi decoction add and subtract on patients with diabetic gastroparesis. METHODS The 200 patients with diabetic gastroparesis from February 2017 to February 2019 were selected and randomly divided into routine treatment group and observation treatment group, 100 cases in each group. The routine treatment group was treated with mosapride citrate tablets on the basis of basic treatment. The treatment group was treated with Junzi Xiaopi decoction on the basis of routine treatment group. The levels of motilin, gastrin, fasting plasma glucose (FPG), homocysteine (Hcy) and serum ferritin (SF) were measured. X-ray barium meal was used to detect gastric emptying time. The total effective rate after treatment and the incidence of adverse reactions were also calculated. RESULTS After treatment, compared with routine treatment group, the expression levels of motilin, gastrin, FPG, Hcy, SF, the symptom score and the incidence of adverse reactions in observation treatment group were significantly lower(P<0.05). The gastric emptying time in the observation treatment group was significantly shorter than that in the routine treatment group(P<0.05). The total effective rate of the observation treatment group after treatment was significantly higher than that of the routine treatment group(P<0.05). CONCLUSION Junzi Xiaopi decoction can effectively improve the clinical symptoms of diabetic gastroparesis patients, improve the total effective rate, and reduce the incidence of adverse reactions.