Abstract: OBJECTIVE Based on one case of vibrio vulnificus infection, to explore how to rationally choose antimicrobial agents by clinical pharmacists, combined with drug sensitivity and drug characteristics. METHODS Clinical pharmacists participated in the treatment of a patient with vibrio vulnificus infection, and provided information and help on the treatment plan from the choice and characteristics of antibacterial agents. RESULTS successfully cured a case of vibrio vulnificus infection by providing a strong clinical pharmaceutical support to the doctor's treatment. CONCLUSION To offer references for formulating a medication plan of vibrio infection patients, clinical pharmacists should fully understand the pathogenic mechanisms of vibrio vulnificus and reasonably select antibacterial drugs based on the characteristics, which presents the important value of clinical pharmacists.