Abstract: OBJECTIVE To explore the clinical efficacy and safety of "Eight Zhes" decoction in the treatment of non-alcoholic steatohepatitis. METHODS A prospective cohort study design was used. Clinical cases of non-alcoholic steatohepatitis were collected. Patients were divided into experimental group and control group according to their treatment intention. Sixty-six cases in the control group were treated with routine western medicine for lifestyle intervention and treatment with polyene phosphatidy-lcholine capsules. Sixty-three cases in the experimental group were treated with integrated traditional Chinese and western medicine, received "Eight Zhes" decoction treatment. The course of treatment was 12 weeks, evaluate the curative effect of TCM symptoms, B-ultrasound, blood-liver function and blood lipid changes in patients. RESULTS The total effective rate of TCM symptoms in the experimental group was significantly higher than that in the control group(P<0.01). The normalization rate of TG and TC in the experimental group was significantly higher than that in the control group(P<0.01 or P<0.05). The normalization rates of ALT and AST in both groups were about 90%, there was no significant difference between the two groups. Besides, according to the results of B-ultrasound, the total effective rate of the experimental group was significantly higher than that of the control group(P<0.05). CONCLUSION The results suggest that, the traditional Chinese medicine "Eight Zhes" decoction can significantly improve the clinical efficacy in the treatment of non-alcoholic steatohepatitis on the bases of routine western medicine.