Abstract: OBJECTIVE To explore the pharmacological mechanism of Jiao-ai Tang by means of network pharmacology. METHODS The active components and gene targets of 7 traditional Chinese medicines were retrieved on the basis of TCMSP. Cytoscape was used to construct compound-target network, compound-target-disease target and target-pathway network, and protein-protein interaction network was constructed according to online STRING database to study the pharmacological mechanism of Jiao-ai Tang. RESULTS sixty-four compounds were obtained through screening, and 32 corresponding key targets were obtained. Protein-protein interaction network contained 20 targets, key targets including Ptgs2, F2, Tnf, Il6, F3, etc. There were 61 items of gene ontology, including 34 items related to biological process, 20 items related to cell composition and 7 items related to molecular function. KEGG channel enrichment analysis of 4 pathways. CONCLUSION This study preliminarily verified the basic pharmacological effect and mechanism of Jiao-ai Tang, and laid a foundation for further exploring its pharmacological effect.