Abstract: The intestinal mucosal barrier can effectively prevent intestinal harmful substances entering the blood and other tissues through the intestinal mucosa, and plays a very important role in maintaining the steady state of the organism and the external environment. However, when the body suffers severe stress, the intestinal mucosal barrier function will decrease. In recent years, the intervention of Traditional Chinese medicine(TCM) opens up a new path for the protection of intestinal mucosal barrier. TCM can repair damaged intestinal mucosal barrier by regulating the tight junction between intestinal epithelial cells, regulating intestinal microecological balance and stimulating intestinal immune response. This article reviews the mechanism of TCM in the protection and repair of damaged intestinal mucosa, aiming to elucidate the important role of TCM in the protection of intestinal mucosal barrier.