Abstract: OBJECTIVE To explore the role of clinical pharmacists in anti-infective pharmacotherapy. METHODS The pharmaceutical practice of a patient with Chryseomonas luteola bloodstream infection and end stage renal disease was analyzed to explore how to make rational anti-infective schedule for infection patients with renal disease. RESULTS Clinical pharmacists actively participated in drug treatment, evaluated anti-infective treatment plans according to the guidelines, and gave recommendations for revision of reasonable anti-infective treatment plans based on drug susceptibility results and past patient history, and finally the infection was effectively controlled. CONCLUSION Infection can affect the quality of life seriously. Clinical pharmacists can help physicians to select rational antimicrobial drugs, usage and dosage, rational drug comnination, pay attention to the side effection, thus to make individual therapeutic schedule and ensure the rational use of antimicrobial drugs for infection patients with renal disease.