Abstract: OBJECTIVE To explore the mode of clinical pharmacists participating in pain treatment, which can better prevent the addiction caused by opioids. METHODS As members of the good pain management team, clinical pharmacists can improve patient compliance and prevent iatrogenic opioid addiction through drug education and monitoring. At the same time, clinical pharmacists also can intervene and guide detoxification treatment for addicted patients. RESULTS Clinical pharmacists play an important role in two patients who were addicted due to nonstandard use of oxycontin, through educating patients, decreasing dosage or re-titrating the therapeutic doses. CONCLUSION The full participation of clinical pharmacists in the pain treatment can effectively prevent opioid addiction, ensure the safety, effectiveness and regulation of drug use.