Abstract: OBJECTIVE To investigate the effects of curcumin on anti-tumor activity and immune function in cervical cancer mice. METHODS Cervical cancer mice model were established by U14 cells inoculated into abdominal cavity and forelimb axillary. The model mice were randomly divided into model group, curcumin group and positive control group, with 10 mice in each group. The model group was given 0.2 mL 0.9% NaCl, the curcumin group was given 100 mg·mL^-1 curcumin, continuous intragastric administration for 14 d, and the positive control group was given 0.2 mL 3 mg·kg^-1·d^-1 cisplatin, once every 3 d, for five times. The morphology of transplanted tumor was compared. The tumor volume and weight were measured and the tumor inhibition rate was calculated. The serum levels of IL-2, TNF-α, IFN-γ, OPN, CEA and SCC-Ag were detected by ELISA. The content of CD3⁺, CD4⁺, CD8⁺ and NKT cells were detected by flow cytometry. RESULTS In the model group, the nuclei were large and hyperchromatic, nucleoplasm increased, and mitosis multiple division. In curcumin group and positive control group, cancer shrunk, nuclei coagulated or fragmented, and pathological mitosis reduced. The levels of tumor volume, weight, IL-2, TNF-a, IFN-γ, OPN, CEA, SCC-Ag and CD8⁺ in curcumin group and positive control group were significantly lower than the model group, and the tumor inhibition rate, CD3⁺, CD4⁺ and NKT cell content were significantly higher than the model group, the differences were statistically significant (P<0.05). CONCLUSION Curcumin can inhibit the anti-tumor activity of cervical cancer mice, the mechanism may be related to the reduction of inflammatory factors and tumor markers by enhancing immune function.