Abstract: Hyaluronic acid(HA) has coming before the public in recent years for its potential application as an efficient tumor-targeting delivery vehicle. The superiority of HA is reflected as its great biocompatibility, biodegradability and special binding ability to CD44 receptor. Thus, in this review, the discussion is focused on the structural modification of HA, the rationale for the use of HA as tumor-specific carrier for drug delivery and research achievements in the field of HA-based nanodrug delivery systems. In addition, the application prospect of HA is prospected.