Abstract: The incidence of liver disease continues to rise and health and quality of life are seriously affected for people. Liver damage is the pathologic status in the liver system, which can lead to cirrhosis, fibrosis and cancer of the liver. Flavonoids are important natural organic compounds that widely distributed in the plant kingdom. Studies showed that flavonoids have significant effects on liver protection. They have broad application prospects for its low toxicity and small side effects. In recent years, domestic and foreign scholars have conducted in-depth research on its mechanism. This paper summarizes the mechanism of anti-hepatic lesion of flavonoids at home and abroad in the past ten years, especially in the past three years.