Abstract: OBJECTIVE To evaluate the effect of plan-do-check-act(PDCA) cycle management method on improving key monitoring drugs control measures. METHODS PDCA cycle management method was applied to improve key monitoring drugs control system, early warning, reward and punishment system as well, control efficacy of key monitoring drugs between July 2016-June 2017(before PDCA implementation) and July 2017-June 2018(after PDCA implementation) was compared. RESULTS After implementation of PDCA cycle management, the DDDs of key monitoring drugs fell from 1 442 055.98 to 1 221 586.24, the sales amount fell from 139 162 725.28 yuan to 123 157 464.54 yuan, the reasonable use rate increased from 61.53% to 87.01%. CONCLUSION Application of PDCA cycle can improve control efficacy of key monitoring drugs.