Abstract: OBJECTIVE To investigate the curative effect of aspergillus oryzae combined with itopril in the adjuvant treatment of chronic gastritis with reflux esophagitis. METHODS Sixty cases of chronic gastritis with reflux esophagitis admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from June 2017 to June 2018 were selected and divided into 2 groups of 30 cases each by random number table method. The control group was given oral itopride hydrochloride tablets, the treatment group was based on the control group of Oral Aspergillus pancreatic enzyme, 2 groups of patients were continuous treatment of 8 weeks. The clinical efficacy, reflux esophageal inflammatory status score, endoscopic grading, SF-36 score, SDS score, SAS score and adverse reactions were observed in the 2 groups. RESULTS After treatment, the total effective rate of the treatment group was significantly better than that of the control group(P<0.05). The scores of retrosternal burning pain, heartburn and acid regurgitation were significantly decreased in the 2 groups, the decrease was more significant in the treatment group(P<0.05). Gastroscopy was significantly improved in both groups, the number of grade 0 and grade 1 patients in the treatment group was significantly higher than that in the control group(P<0.05), and the number of grade 3 and grade 4 patients was significantly lower than that in the control group. SF-36 scores were significantly increased in both groups, the SF-36 score of the treatment group was significantly increased(P<0.05). SDS and SAS scores of the 2 groups were significantly lower than those before treatment(P<0.05). The degree of decline was more significant in the treatment group(P<0.05). CONCLUSION The use of aspergillus oryzae combined with itopride adjuvant treatment of chronic gastritis with reflux esophagitis has a good clinical effect, can effectively alleviate the clinical symptoms, worthy of clinical application.