Abstract: OBJECTIVE To optimize the extraction process of total volatile components of Aurantii Fructus and Cyperi Rhizoma. METHODS The total volatile oil from Aurantii Fructus and Cyperi Rhizoma was extracted by steam distillation and the yield of volatile oil was calculated. The contents of the main effective components of total volatile oil such as limonene in Aurantii Fructus, α-geranyl ketone and geranyl ketone in Cyperi Rhizoma were determined by GC. The information entropy principle was applied to analyze the weight of the volatile oil yield and the contents of three effective components, and the comprehensive score M was obtained as the evaluation index. Box-behnken model analysis on M was used to select the optimal extraction process. RESULTS The optimum extraction technology was as followed:the ratio of liquid to material was 14 times; soaking time was 1.1 h and the extraction time was 7 h. The difference between the actual M value and the best M value of the model was less than 1%, which indicated that this experiment was predictable and the reliability of the model was high. CONCLUSION The optimum extraction technology based on response surface method and information entropy method can effectively improve the content of total volatile components of Aurantii Fructus and Cyperi Rhizoma.