Abstract: OBJECTIVE To optimize the extraction technology of Qinhuang gel. METHODS With the transferring rate of baicalin, aloe emodin, rhein, emodin, chrysophanol, physcion as index, orthogonal design L9(3⁴) was carried out for the optimum extraction technology of Qinhuang gel by water and ethanol. RESULTS The optimum extraction technology by water were as follows:6-fold water, soaking 0.5 h, reflux extracting 2 times and 1.5 h each time; the optimum extraction technology by ethanol were as follows:8-fold 40% ethanol, reflux extracting 3 times and 1.0 h each time. CONCLUSION The extraction technology of Qinhuang gel optimized by multicreteria comprehensive assessment is reasonable and practical.