Abstract: OBJECTIVE To evaluate the effect of different β-blockers for the efficacy of ejection fraction preserved heart failure by network meta-analysis. METHODS Eight databases were searched for randomized controlled trials(RCTs) of different β-blockers for patients with ejection fraction preserved heart failure. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Statistical analysis was performed by STATA 14 software and R 3.4.3 software, gemtc and rjags packages. RESULTS A total of 50 RCTs involving 4 089 patients were included. The results of network meta-analysis showed that compared with not use β-blockers, β-blockers could improve clinical efficacy, reduce heart rate(P<0.05). In the control of blood pressure, the effects of metoprolol, carvedilol, and arotinolol were better than those without β-blockers(P<0.05). The results of area under the cumulative ranking curve which ranked effectiveness of all β-blockers showed that carvedilol had the best effectiveness. CONCLUSION The current evidence shows that carvedilol may be effective in heart failure with reduced ejection fraction treatment. Due to limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.