Abstract: OBJECTIVE To observe theanalgesia effects of bhutto butorphanol tartrate combined dezocine in the patients after total hip replacement. METHODS From August 2015 to January 2018, used the retrospective research methods, 58 patients underwent total hip replacement were selected in Dongfeng Hospital Affiliated to Hubei University of Medicine as the research object, all the patients were divided into the observation group of 30 patients and the control group of 28 patients accorded to the different postoperative analgesic drugs, two groups were given the combined spinal epidural anesthesia, the control group were given postoperative dezocine epidural analgesia, the observation group were given postoperative bhutto butorphanol tartrate combined dezocine epidural analgesia, recorded two groups of analgesic effect and prognosis. RESULTS The postoperative 2, 6, 12 and 24 h pain VAS scores in the observation group were significantly less than those in the control group(P<0.05). There were no significant difference in the contrast of Ramsay scores at different time points between the two groups. The incidence of adverse reactions of postoperative such as urinary retention, itching, respiratory depression, nausea and vomiting was 6.7% in the observation group, while it was 53.6% in the control group. The incidence in the observation group were significantly lower than that in the control group(P<0.05). There were no significant difference between the two groups in preoperative 1 d adrenaline and norepinephrine, and at postoperative 24 h they were increased significantly, and at postoperative 72 h they were gradually returned to the level of preoperative 1 d. The fluctuation amplitude of the observation group were significantly less than that of the control group(P<0.05). CONCLUSION The bhutto butorphanol tartrate combined dezocine for postoperative analgesia in patients undergoing total hip replacement can enhance the analgesic effect in maintaining sedative effect, relieve stress response, reduce the incidence of adverse reactions after operation.