Abstract: OBJECTIVE To optimize the the preparation process of the mixed volatile oil of Liqi Huoxue Recipe wrapped with b-cyclodextrin. METHODS Saturated aqueous solution method and grinding method were used to encapsulate the mixed volatile oil. The optimum encapsulation method was selected. The encapsulation conditions were optimized by orthogonal design. The weight coefficients of each index were determined by entropy weight method. Inclusion complexes were verified by TLC and IR. RESULTS The best inclusion method was saturated aqueous solution method. The ratio of volatile oil to b-cyclodextrin was 1:10, the rotational speed was 50 r·min^-1, and the temperature was 40℃. CONCLUSION The optimized inclusion process is simple, stable and has high inclusion rate and high yield of volatile oil.