Abstract: OBJECTIVE To improve the identification of polymyxin B for injection-associated adverse reactions such as facial pigmentation, and provide recommendations for appropriate treatment. METHODS One case of facial pigmentation induced by polymyxin B for injection in the anti-infective was described and analyzed correlation by Knott's score. The literature was also reviewed to make a summary of cutaneous. RESULTS This patient was diagnosed with a liver transplant and was treated with polymyxin B for infection after surgery, facial hyperpigmentation was occurred. CONCLUSION Polymyxin B causes an adverse reaction to facial pigmentation, which is not mentioned in the specification, and avoids exposure to sunlight, especially ultraviolet rays, during the administration.