Abstract: The rate limiting barrier of the stratum corneum influences the transdermal performance in most drugs. Strong points such as deep-layer skin and systemic circulation delivery, accessible fabrication and safety in use make transethosome welcomed worldwide. It is a new delivery carrier that transethosome acts as for percutaneous penetration. Because of the high deformability, promotion in drug percutaneous penetration, sustained release and drug degradation prevention, transethosome owns a wide application future and development prospect in the field of drug percutaneous absorption. To provide references for the future development in terms of transdermal drug delivery system, a brief review is summarized through revising domestic and foreign literatures.