Abstract: OBJECTIVE To assess the prevalence of using potentially inappropriate medication(PIM) in older neurology outpatients using the Screening Tool of Older Persons' Prescriptions(STOPP) criteria. METHODS A retrospective survey was adapted to include 5 185 neurology outpatients aged ≥ 65 years from Second Affiliated Hospital, Zhejiang University, School of Medicine, from January 2016 to March 2016. PIM were defined using the STOPP criteria. A multivariate logistic regression study was used to identify the risk factors for PIM. RESULTS Based on STOPP criteria, 446 PIM were found to affect 290 patients. Of the 5 185 participants, 290(5.59%) were prescribed at least one PIM. The three most common prescribed PIM were as follows:① long-acting benzodiazepines; ② aspirin with a history of peptic ulcer disease without a histamine H2 receptor antagonist or proton pump inhibitor; ③ long-term neuroleptics in Parkinson Disease patients. Based on multivariate logistic regression analysis, the number of prescription medications (OR=1.145; 95%CI:1.109-1.182) and the number of diagnoses (OR=1.208; 95%CI:1.111-1.313) were significantly associated with PIM. CONCLUSION The numbers of medications and diagnoses were closely associated with PIM in older neurology outpatients. More attention should be paid to elderly patients with multiple medications and diagnoses.