Abstract:
OBJECTIVE To investigate the clinical effect of naloxone combined with erythropoietin(EPO) injection in the treatment of neonatal hypoxic-ischemic encephalopathy(HIE).
METHODS From September 2014 to September 2017, 216 children with HIE were selected as subjects in the pediatric department of Qinghai Red Cross Hospital, and randomly divided into observation group and control group, 108 cases in each group. The observation group was treated with naloxone combine EPO injection and the control group was treated with naloxone. The clinical efficacy, clinical symptom improvement time, score of Bailey infant development scale, score of Gesell scale, blood cell count, serum neurologic function, serum cytokines and sequelae incidence were compared between the two groups.
RESULTS The total effective rate of the observation group(95.4%) was significantly higher than that of the control group(85.2%)(
P<0.05). The moderate efficiency and severe efficiency of the observation group were significantly higher than that of the control group(
P<0.05). The recovery time of consciousness, original reflex and muscle tension in the observation group were significantly shorter than those in the control group(
P<0.05). The neonatal behavioral neurological assessment(NBNA) scores in the two groups was had no significant difference one week after treatment, while the scores in the observation group were significantly higher than those in the control group 2 weeks after treatment(
P<0.05). The mental development index score and psychomotor development index score of the 3 months old and 6 months old children in the observation group were significantly higher than those in the control group(
P<0.05). The development quotient scores of the large kinetic energy zone, the fine motor energy zone, the linguistic energy zone, the individual community energy zone and the social adaptive energy zone of the observation group in Gesell scale were significantly higher than the control group(
P<0.05). After treatment, the level of hemoglobin, reticulocyte count, platelet count in the observation group were significantly higher than that in the control group(
P<0.05). The serum neuron-specific enolase, myelin basic protein, S100-β level in the observation group were significantly lower than that in the control group(
P<0.05). The serum tau, endogenous activin A, TNF-α level in the observation group were significantly lower than that in the control group(
P<0.05). There was no significant difference in the incidence of sequelae between the two groups.
CONCLUSION The efficacy of naloxone combined with EPO injection in the treatment of HIE is significant, which can effectively improve the nervous system function of children and reduce the incidence of sequelae.