Abstract: OBJECTIVE To evaluate the efficacy and security of a single dose of perioperative ketorolac on postoperative analgesia by meta-analysis. METHODS Followed the PRISMA statement guidelines. A wide search was performed to identify randomized controlled trials that evaluated the effects of a single dose of systemic ketorolac on postoperative pain, opioid consumption and adverse reactions. Meta analysis was performed using a random-effects model. RESULTS Eleven randomized clinical trials with 606 subjects were included. The result showed statistically differences for ketorolac over placebo for 0, 4, and 8 h after surgery, but not at 24 h. Preemptive analgesia with ketorolac could reduce the use of postoperative opioids(morphine)MD=-4.25, 95%CI(-8.16, -0.35), P=0.03. Postoperative nausea and vomiting were decreased by ketorolac, with an RR sratio (95%CI) of 0.68 (0.51, 0.90) (P=0.006), and did not increase the occurrence of serious adverse reactions. CONCLUSION The available clinical studys indicate that ketorolac is effective for perioperative advanced analgesia and can reduce postoperative opioid(morphine) usage and also decrease nausea or vomiting.