Abstract: OBJECTIVE To understand the characteristics and mechanism of flavonoids on anti-arrhythmia in depth. METHODS Through the method of literature research, the research progress of flavonoids on anti-arrhythmia from the perspective of ion channels were summarized. RESULTS Different flavonoids had different effects on some types of sodium, potassium and calcium channels, which constitute the material basis of their anti-arrhythmia effect. CONCLUSION Flavonoids have good preventive effects on arrhythmia, and have important clinical significance and application prospects for the in-depth development and utilization.