Abstract: OBJECTIVE To analyze the rationality of levofloxacin in the inpatient department according to the renal function. METHODS Two hundred cases of patients treated with evofloxacin in the inpatient department from 2016.7.1-2017.6.30 were checked for detailed analysis in random using interval sampling method. RESULTS There were 100 cases of male and 100 cases of female patients, with the age of (69.1±17.3) years, 43 cases of irrational drug use, 22 cases of adverse reactions, elderly patients and patients with chronic renal insufficiency were more common. There were 31 patients whose estimated glomerular filtration rate <50 mL·min^-1·(1.73 m²)^-1, with an average age of (80.3±16.1)years, 30 cases was overdose and 8 cases' serum creatinine remained within the normal range. CONCLUSION In 2017, the dose of levofloxacin was not adjusted well according to the renal function, especially in the elder patients. Clinical pharmacists shall develop multidisciplinary cooperation models with the aid of computer to improve the rational use of levofloxacin.