Abstract: OBJECTIVE To study efficacy and safety of Tianzhi granules combined with fluvoxamine in the treatment of adolescents with obsessive-compulsive disorder. METHODS A total of 165 young patients with obsessive-compulsive disorder were admitted to the Second Affiliated Hospital of Xinxiang Medical College. They were randomly divided into control group(82 cases) and observation group(83 cases). Fluvoxamine was taken oral in control group, observation group took Tianzhi granules combined with fluvoxamine, all patients were treated for 8 weeks. Compared national institutes of clinical efficacy, Yale-Brown obsessive-compulsive symptoms(Y-BCOS) score, Hamilton anxiety(HAMA) score, WHO quality of life measurement scale (WHOQOL-BREF) score, adverse reaction, assessment of cognitive function used neuropsychological status assessment tool(RBANS). Serum monoamine neurotransmitters serotonin(5-HT) and serum brain-derived neurotrophic factor(BDNF) levels were measured and compared before and after treatment. RESULTS The total effective rate in observation group was significantly higher than control group, with statistical significance(P<0.01). Before treatment, the Y-BCOS, HAMA, WHOQOL-BREF and RBANS score, the 5-HT and BDNF in 2 groups were comparable. After treatment, compared with the control group, the Y-BCOS and HAMA score in observation group decreased(P<0.05), the WHOQOL-BREF, RBANS, BDNF score and 5-HT increased(P<0.05). The number of adverse reaction and treatment emergent symptom scale in the observation group was significantly lower than it in the control group. CONCLUSION Tianzhi granules can improve the clinical efficacy of fluvoxamine in treatment of obsessive-compulsive disorder in adolescence, and has fewer adverse reactions. It can effectively adjust cognitive ability and improve the quality of life of patients.