Abstract: OBJECTIVE To summarize the research and application of elastic lipid vesicles in transdermal delivery systems in recent years, and to provide reference for future research in this field. METHODS The literature on the classification and preparation of elastin lipid vesicles, the mechanism of penetration promotion, and the application of the lipid-containing lipid vesicles were reviewed by referring to the related literature on transdermal delivery of elastic lipid vesicles for the past 5 years direction. RESULTS Elastin lipid vesicles had good deformability and skin permeability, and could pass through the stratum corneum, which was more conducive to drug absorption into the blood, improved bioavailability, and was more conducive to skin drug use. CONCLUSION The transdermal delivery system of elastin lipid vesicles is a safe and effective route of administration, with better compliance and promising application in transdermal delivery.