Abstract: OBJECTIVE To analyze the correlation between drug resistance of Acinetobacter baumannii and the frequency of antibiotics used in our hospital, and the correlation between drug resistance of Acinetobacter baumannii to different antibiotics. METHODS The susceptibility of related antibiotics to Acinetobacter baumannii was determined by disk agar diffusion method. According to the principle and method of defined daily dose(DDD) value recommended by WHO, the DDD value was determined and the antibiotics use density(AUD) was calculated. SPSS 17.0 was used to analyze the data. RESULTS The detection rate of Acinetobacter baumannii in The First Affiliated Hospital of Shantou University Medical College decreased year by year from 2013 to 2017, and the total strength of the related antibiotics decreased year by year from 2014. The resistance rates of Acinetobacter baumannii to ceftriaxone, cefepime and ciprofloxacin decreased after 2014. The resistance rates to imipenem decreased after 2015. Enter a downward trend. There was no significant correlation between AUD and drug resistance rate of Acinetobacter baumannii (P>0.05). Most of the drug resistance rates of Acinetobacter baumannii were correlated with tigacycline except for tigacycline (P<0.05). CONCLUSION Strengthening hospital management and rational use of antibiotics is the key to treat Acinetobacter baumannii infection and reduce the drug resistance rate, but also to understand the high incidence of drug resistance of Acinetobacter baumannii, in order to better control infection and reduce the incidence of drug resistance.